Total Synthesis and Determination of Absolute Configuration of Carthamin ; A Red Pigment in the Petals of Safflower

红花花瓣的红色着色成分红花素的绝对构型被确定为S，S。此外，红花素前体、红花黄色素B、红花红色素A、红花红色素C和异红花红色素C以C-葡萄糖基喹查尔酮为共同结构单元的其他黄色着色成分的绝对构型也以相同的方式被确定为S，S。首先合成了含有链状葡萄糖的红花黄色素模型化合物B，并对其水解产生少量红花素模型化合物，以及红花素的生物合成途径进行了研究;其次，我们首次合成了山葵茎点霉的代谢产物之一，具有高度氧化结构，与红花素一样是酮-烯醇互变异构体的混合物。

Absolute configuration of Carthamin which is the red coloring component of safflower petals, was determined to be S, S.Furthermore, absolute configurations of the other yellow coloring components in which carthamin precursor, safflower yellow B, safflomin A, Safflomin C, and isosafflomin C bear C-glucosylquinochalcone as a common structural unit, were also determined to be S, S in the same way. Model compound of safflower yellow B which includes a chain-type glucose was first synthesized and its hydrolysis produced a small amount of carthamin-model compounds, as well as carthamin's biosynthetic pathway.Next, we first synthesized Wasabidienone A which is one of the metabolites of phoma wasabidiae, highly oxidized structure, and a mixture of keto-enol tautomers like carthamin.