Epigenetic regulation of immune memory

免疫记忆细胞从动态和短暂的免疫反应中产生，提供两种关键能力：在再次感染时产生快速回忆反应，但也能持续数十年。该项目旨在通过利用尖端的细胞和染色质生物学技术以及生物信息学管道来确定polycomb抑制复合物如何调节免疫细胞的命运。拟议研究的预期成果包括对免疫细胞分化和长寿所需的表观遗传编程的关键见解。这应该会带来重大的好处，例如知识创造，可能会导致重新编程细胞行为的技术的发展，以及对澳大利亚研究认可和能力的贡献。

Immune memory cells emerge from the dynamic and transient immune response to deliver two critical abilities: to produce rapid recall responses upon reinfection but also to persist for decades. This project aims to define how the polycomb repressive complexes regulate immune cell fate, by utilising cutting-edge cell and chromatin biology techniques coupled with bioinformatic pipelines. Expected outcomes of the proposed research include key insights into epigenetic programming required for immune cell differentiation and longevity. This should provide significant benefits such as knowledge creation that may lead to development of technology that reprograms cell behaviour, and contribution to Australian research recognition and capacity.