Circadian photoreceptor sensitivity and impacts of modern lighting on sleep

光具有强大的非视觉效果，包括对睡眠的影响。这些非视觉效应是由眼睛中对蓝光最敏感的细胞介导的。人们对光的非视觉效应的敏感度存在很大的个体差异，这一点还不为人所知，这将使人们对现代社会普遍存在的次优睡眠有很大的洞察力。这项研究将是第一次系统地研究蓝光对睡眠影响的个体差异，并将揭示负责蓝光对睡眠影响的基因(OPN4)的变化是如何导致这些差异的。这将导致可扩展的个性化解决方案，以解决现代光环境如何影响睡眠这一尚未解决的问题。

Light has powerful non-visual effects, including effects on sleep. These non-visual effects are mediated by cells in the eye that are most sensitive to blue light. There are large individual differences in sensitivity to non-visual effects of light that are not understood and that would give great insight into suboptimal sleep, which has become widespread in modern society. This study will be the first systematic examination of individual differences in the effect of blue light on sleep and will uncover how alterations in the gene responsible for the effects of blue light on sleep (OPN4) contribute to these differences. This will lead to scalable individualised solutions to the unmet problem of how modern light environments impact sleep.