Molecular biological changes of ADP/ATP carrier protein in cardiomyopathic hamsters

ATP/ADP载体蛋白（AAC）是线粒体内膜上的一种重要蛋白，它负责ADP和ATP在细胞质和线粒体内的交换。本文研究了J-2-N心肌病仓鼠、肾血管性高血压大鼠和糖尿病大鼠心肌中ACC的含量。另一方面，心肌病仓鼠的ACC m-RNA水平升高。肾血管性高血压大鼠（2K-1C）术后8周出现左室肥厚和肌球蛋白同工酶谱异常改变。手术组ACC蛋白含量明显降低。在链脲佐菌素诱导的糖尿病大鼠中，ACC蛋白含量显著增加，提示AAC蛋白的变化在心肌病、心肌肥厚和糖尿病心脏的血流动力学改变中起重要作用。此外，这些变化被认为是一种适应，有助于维持有效的力量发展与低氧和能量利用在一些心脏疾病。

The ATP/ADP carrier protein (AAC) is an integral protein present in the inner mitochondrial membrane that performs the exchange of cytoplasmic and intramitochondrial ADP and ATP.The ACC content of the myocardium was studied in J-2-N cardiomyopathic hamster, renovascular hypertensive rats and diabetic rats.The content of ACC protein was significantly decreased in cardiomyopathic hamster. On the other hand, ACC m-RNA level was increased in cardiomyopathic hamster. In renovascular hypertensive rat (2K-1C), left ventricular hypertrophy and abnormal changes of myosin isoenzyme pattern were observed 8 weeks after an operation. The content of ACC protein was significantly decreased in operated rats. In streptozotocin-induced diabetic rats, the content of ACC protein was significantly increased.These results suggest that the changes of the AAC protein play an important role in the pathogenesis of hemodynamic alteration of cardiomyopathy, hypertrophy and diabetic hearts. Moreover, these changes were considered to be an adaptation which contribute to maintain efficient force development with low oxygen and energy utilization in several cardiac deceases.