Study of the fluoride release restorative material on root caries of elderly patients

本研究旨在探讨一种新研制的修复材料对老年人根面龋或继发龋的治疗效果。新开发的修复材料具有抗离子和氟化物释放特性的综合效果。本研究首先是研制一种新型的以甲硝唑为主的抗菌药物与氟离子玻璃离子水门汀的混合物组成的修复材料。通过对新研制的牙体材料的抗压强度、表面硬度、表面溶解度、氟释放量、牙釉质和牙本质的氟吸收量、牙体结构的抗酸能力和抗菌效果的测试，结果表明：新研制的牙体材料在2个月以上的时间内具有持续的氟释放能力。新研制的修复材料的抗菌持久效果，对材料本身没有太大的影响，只是有所减弱，但对于修复体来说是足够的。用电子探针X射线微区分析仪对材料-牙釉质和牙本质界面进行分析，结果表明，释放氟的实验材料接触部分的牙釉质和牙本质壁区有氟吸收。抗酸能力测试是通过比较釉质和牙本质样本与实验材料接触2个月后的溶解钙量，结果显示其溶解钙量小于与无氟释放材料样本（保存在去离子水或无氟释放材料中）接触的溶解钙量。实验性释氟材料可提高牙釉质和牙本质的抗酸能力。本研究证实了这种新研制的修复材料对老年人根面龋有一定的治疗作用，并能有效地预防原发龋和继发龋。

The purpose of this study, was to investigate the effect of a newly developed restorative material on the root caries of elderly patients or secondary caries. The newly developed restorative material has combined effect anti-canons & fluoride release properies. The study, first was to make the newly developed restorative material which composed of fluoride release glass ionomer cement & a mixture of anti-bacteria drug mainly metronidazole. The newly developed restorative material was tested for compressive strength, surface hardness, surface solubility, fluoride release, fluoride uptake for enamel and dentin, acid resistance of the tooth structures and it's anti-bacterial effect.The following results were obtained ;The sustained fluoride release from the newly developed restorative material was observed up more to 2 months period. The anti-bacterial sustained effect of newly developed restorative material, did not had big change on the material but was weaked, but sufficiently for restoration. Analysis material-enamel and dentin interface using an electron probe x-ray microanalyzer showed the fluoride uptake for enamel and dentin wall areas on contact parts with the fluoride releasing experimental materials. The test of acid resistance was by comparing the amount of dissolved calcium from enamel and dentin specimens in contact with experimental materials for 2 months ; it showed that there were smaller amount than those in contact with without-fluoride release materials sample(kept in deionized water or non-fluoride release materials). The acid resistance of fluoridated enamel and dentin specimens by experimental fluoride releasing materials was increased. From this study, it was confirmed that the newly developed restorative material is useful to root caries of elderly and it could prevent primary or sccondary caries.