Novel functions of phospholipases

三个新的磷脂酶的生理作用进行了分析，通过生产敲除动物。磷脂酶是I型血小板活化因子乙酰水解酶（PAF-AH（I））、II型血小板活化因子乙酰水解酶（PAF-AH（II））和磷脂酰丝氨酸特异性磷脂酶A1（PS-PLA 1）。对于PAF-AH（I）和PS-PLA 1，我们已经制造了敲除小鼠，对于PAF-AH（II），我们已经制造了敲除秀丽隐杆线虫，因为生物体表达PAF-AH（II）的哺乳动物同源物。表：基因敲除动物的表型动物表型PAF-AH（I）小鼠精子形成异常PAF-AH（II）秀丽隐杆线虫表皮形成异常PS-PLA 1小鼠T细胞发育异常由于这些表型不是预期的，因此建议每种磷脂酶具有新的功能，这些功能应在进一步的研究中解决。

Physiological roles of three novel phospholipases have been analysed by producing knockout animals. The phospholipases are type I platelet-activating factor acetylhydrolase (PAF-AH (I)), type II platelet-activating factor acetylhydrolase (PAF-AH (II)), and phosphatidylserine-specific phospholipase A1 (PS-PLA1). For PAF-AH (I) and PS-PLA1, we have made knock out mice, and for PAF-AH (II), we have made knockout C.elegans, as the organism express mammalian homologue of PAF-AH (II). The phenotype of each animal are shown in table ;Table : Phenotype of knockout animalsanimals phenotypePAF-AH (I) mice abnormality on sperm formationPAF-AH (II) c.elegans abnormality in epidermis formationPS-PLA1 mice abnormality in T cell developmentAs these phenotype are not expected, novel function for each phospholipase is suggested, which should be solved in further studies.