Molecular analysis of hepatitis G virus and TT virus in pediatric population

庚型肝炎病毒(HGV)和TT病毒(TTV)都是输血传播源。因此，我们在血友病患者和儿童骨髓移植受者中同时研究了这两种病毒。关于HGV感染，我们的研究目的是阐明这些儿科患者的患病率和自然病程。HGV在未灭菌的凝血因子浓缩物治疗的血友病患者中普遍存在，但与丙型肝炎病毒感染相反，HGV感染经常观察到自发恢复(BR J Haematol 1998,102：616-621)。在接受血液系统恶性肿瘤治疗的儿童中，这些免疫抑制的患者明显可以在没有检测到抗E2抗体的情况下从HGV感染中恢复，一些理应从HGV感染中恢复的患者在化疗或骨髓移植期间随后免疫抑制时仍可能恶化(血液1999，93：721-727)。接下来，我们检查了TTV是否以及如何感染儿童。TTV病毒血症在健康人群中的高发病率，包括未输血的小婴儿，清楚地表明最初被确定为输血传播剂的病毒更频繁地通过非肠道传播(Lancet 1998,9136：1309-1310)。我们还发现，在我们的血友病队列中，活动性TTV感染的患病率高于年龄匹配的正常对照组，并怀疑TTV可能通过加热的血液制品传播(Lancet 1998,9136：1308-1309)。

Both hepatitis G virus (HGV) and TT virus (TTV) are transfusion-transmissible agent. Thus, we investigate both viruses at the same time in hemophilics and pediatric bone marrow transplant recipients. Concerning HGV infection, the objectives of our study was to clarify the prevalence and natural course in these pediatric patients. HGV are prevalent in hemophiliacs treated with unsterilized coagulation factor concentrates, however in contrast to hepatitis C virus Infection, spontaneous recovery was frequently observed in HGV infection (Br J Haematol 1998, 102 : 616-621). In children treated for hematological malignancy, these immunosuppressed patients can apparently recover from HGV infection without detectable anti-E2 antibody and some patients who supposedly recovered from HGV infection can nonetheless suffer exacerbation when subsequently immunosuppressed during chemotherapy or bone marrow trasplantation (Blood 1999, 93 : 721-727).Next, we examined whether and how did TTV infect in children. The high incidence of TTV viremia in healthy population including small infants without transfusion made it clear for the virus initially identified as a transfusion-transmitted agent to transmit non-parenterally more frequently (Lancet 1998, 9136 : 1309-1310). We also found a higher prevalence of active TTV infection in our haemophiliac cohort than that in age-matched normal control and suspect the possible transmission of TTV through heat-treated blood products (Lancet 1998, 9136 : 1308-1309).