The Relationship between schizophrenic thought disorder and cognitive function

我们使用思维障碍指数（TDI）和波恩基本症状评估量表（BSABS）对缓解期精神分裂症患者的思维障碍进行了检查，TDI是一种用于评估从轻微到公然的23种思维障碍的工具，BSABS是一种用于评估主观体验的工具。本研究结果提示，TDI的“特异质言语化”因子是精神分裂症思维障碍的特征，精神分裂症特有的主观症状是由基本心理学意义上的“思维”、“语言”、“记忆”、“注意”障碍所致。为探讨精神分裂症思维障碍与认知功能障碍的关系，采用TDI、威斯康星州卡片分类测验（WCST）、韦氏记忆量表修订版（WMS-R）、韦氏成人智力量表修订版（WAIS-R）对22例精神分裂症患者进行评定。患者在WCST中表现出高的TDI分和精神分裂症特有的子量表模式，低的实现类别和高的持续错误，TDI总分与WCST变量之间没有相关性。当根据TDI总分将患者分为高、低TDI评分组时，我们发现仅在高TDI组中TDI评分与WCST达到的类别之间存在边缘负相关。这些研究表明，工作记忆在一定程度上与精神分裂症患者的思维障碍的严重程度有关。此外，他们表现出较差的性能，除了注意力/集中指数的WMS-R。TDI总分与WAIS-R的“相似性”、“图片排列”指数呈显著相关，WMS-R的言语记忆指数与WAIS-R的“相似性”、“图片完成”、“图片排列”指数呈显著相关。提示精神分裂症思维障碍与言语范畴化、抽象化、概念化有关。

We examined thought disorder in remitted schizophrenics using the Thought Disorder Index (TDI), an instrument for assessing 23 categories of thought disorder ranging from subtle to flagrant, and Bonn Scale for the Assessment of Basic Symptoms (BSABS), and instrument for assessing subjective experiences. The result of this study suggest that "idiosyncratic verbalization" factor of TDI is characteristic of schizophrenic thought disorder and the subjective symptoms specific to schizophrenia are due to disturbances of "thought", "language", "memory", "attention" in terms of elementary psychology. To elucidate the relationship of schizophrenic thought disorder with the cognitive dysfunction, we evaluate 22 schizophrenics by the TDI, Wisconsin Card Sorting Test (WCST), Wechsler Memory Scale-Revised (WMS-R), Wechsler Adult Intelligence Scale-Revised (WAIS-R). The patients showed high TDI scores with a sub-scale pattern specific to schizophrenia, and low achieved categories and high perseverative errors in WCST, and no correlation was found between total TDI score and WCST variables. When the patients were divided into high and low TDI score groups according to the total TDI scores, we found a marginal negative correlation between TDI scores and WCST achieved categories only in the high TDI groups. These suggest that working memory is partly associated with a severity of disordered thinking in a subset of schizophrenia. Also, they showed poor performance except attention/concentration index of WMS-R. total TDI scores significantly correlated with "similarities" and "picture arrangement" index of WAIS-R, and verbal memory index of WMS-R significantly correlated with "similarities", "picture completion" and "picture arrangement" index of WAIS-R. these suggest that schizophrenic though disorder related to verbal categorization and abstraction, conceptualization.