The relationship between serum Angiostatin levels, tumor angiogenesis and distant metastasis of the oral cancer

本研究以1993 ~ 1997年在我科治疗的59例口腔鳞状细胞癌患者为研究对象。肿瘤血管生成与远处转移呈显著相关（p<0.05），表明肿瘤血管生成可作为肿瘤转移的预测因子。我们在1999年第44届日本口腔颌面外科学会年会上报道了肿瘤血管生成与转移的关系。组织学恶性程度与肿瘤转移呈显著相关。而p53基因、T分型与转移无明显差异。我们在第45届日本口腔颌面外科学会年会上（2000年）报道了这一结果。我们无法测量血清血管抑制素水平，因为血清纤溶酶原水平很高。Linder报道尿白蛋白水平与血管抑制素之间有明显的相关性（p=0.003）。我们测量了8例口腔癌患者10个样本的尿白蛋白水平。在引起肺转移的病例中，白蛋白浓度在术前值较高，在术后值有所提高。血管生成因子与血管生成抑制剂之间的失衡导致肺转移。

This study was considered 59 patients of oral squamous cell carcinoma who were treated at our department from 1993 to 1997. A significant relation was evident between the tumor an angiogenesis and distant metastasis (p<0.05), indicating that the tumor angiogenesis could be served as a predictor for metastasis. We reported the relationship between tumor angiogenesis and metastasis in 44th annual meeting Japanese society of Oral and Maxillofacial Surgeons (1999). And a significant relation was evident between the degree of histological malignanc and metastasis. However, there was no significant difference between p53 gene, T classification and metastasis. We reported it in 45th annual meeting Japanese society of Oral and Maxillofacial Surgeons (2000). We could not measured serum Angiostatin levels, because serum plasminogen levels were high. Linder reported that a significant relation was evident between urine albumin levels and Angiostatin (p=0.003). We measured urinary albumin levels of the oral cancer 8 cases, 10 samples. In the case which caused lung metastasis, the albumin concentration showed the high value in the preoperation, and it was improved in the postoperation. The imbalance between angiogenesis factor and angiogenesis inhibitor caused lung metastasis.