Multidisciplinary study on changes of periodontal tissue with aging, and its clinical application

1.系统状态随增龄的变化：1）免疫功能和牙周状态：Fcγ RIIIb-Na 1多态性与牙周炎抵抗力相关（宫崎& Yoshie），牙齿> 19颗的老年人血清IgG 2水平较高（Nakashima）。2）骨矿物质密度和牙周状况：健康的牙周组织被认为是重要的，以维持骨密度的腰椎（Nitta）。3）全身性疾病和牙周再生：GBR在老年大鼠模型中的骨修复中也是有效的（Ohta）。4）牙周再生：BMP在腭部位的骨形成不受衰老的影响（Kawanami）。牙周组织和细胞的增龄变化：1）牙周细胞与牙周致病菌的反应：A。伴放线菌毒素诱导小鼠肺泡巨噬细胞凋亡（Kowashi & Nishihara）。2）胶原代谢：在从人牙龈和牙周膜获得的成纤维细胞中观察到弹性蛋白和胶原蛋白之间的功能差异（Yajima）。3）细胞生物功能的变化：低功率激光照射对细胞增殖、炎症、骨代谢、单克隆抗体被动免疫在牙周炎动物模型中有效（Abiko）。4）牙周膜中的Malassez上皮残余物：Malassez上皮残余物被认为参与牙骨质修复（Ogawa）。

1. Changes in systemic status by aging :1) Immunological function and periodontal status : FcγRIIIb-Na1 polymorphism was associated with the resistance to periodontitis (Miyazaki ＆ Yoshie), and serum IgG2 was higher in elder population with > 19 teeth (Nakashima).2) Bone mineral density and periodontal status: Healthy periodontitum was considered to be important to maintain the bone density of the lumbar vertebra (Nitta).3) Systemic disease and periodontal regeneration: GBR was also effective in the bone repair in older rat model (Ohta).4) Periodontal regeneration: Bone formation in palatal sites by BMP was not affected by aging (Kawanami).2. Changes in periodontal tissue and cells by aging :1) Reaction of periodontal cells with periodontopathic bacteria : A. actinomycetemcomitans induced apoptotic cell death of murine alveolar macrophages (Kowashi ＆ Nishihara).2) Collagen metabolism : Functional differences between elastin and fibrillin were observed in fibroblasts obtained from human gingiva and periodontal membrane (Yajima).3) Changes in cell-biological functions: Radiation of low-power laser has effects on cell proliferation, inflammation, bone metabolism, and passive immunization with monoclonal antibodies was effective in animal model with periodontitis (Abiko).4) Epithelial rests of Malassez in periodontal membrane : Epithelial rests of Malassez is considered to be involved in cementum repair (Ogawa).