Effect of endothelin receptor antagonist on the liver graft

肝切除术后肝细胞癌（HCC）的预后有所改善。本研究旨在确定影响无病生存期的独立危险因素。肝炎活动性采用组织活动指数（hii）评分进行分级，该评分由Knodell等人提出。比例风险分析显示了以下结果。患者的年龄、吲哚菁绿潴留率、肿瘤结节数、显微肿瘤包膜浸润及门静脉浸润、HAI评分评价炎症活动性是影响长期无复发生存的独立因素。通过多因素分析，除了年龄、肝脏储备和肿瘤特征外，炎症活动的重要性也被证实是复发的危险因素。为了实现更长的无病生存，不仅要早期发现，而且要抑制共存的肝炎是先决条件。

The prognosis hepatocellular carcinoma (HCC) has been improved after hepatic resection. This study was undertaken to determine independent risk factors affecting the length of disease-free survival. Activity of hepatitis was graded by the histological activity index (HAI) score, which was proposed by Knodell et al. Proportional hazard analysis demonstrated thefollowing results. The independent factors for long-term survival without recurrence were the patients' age, indocyanine green retention rate, number of tumor nodules, microscopic tumor capsular invasion and portal infiltration, and inflammatory activity assessed by HAI score. The importance of inflammatory activity in addition to aging, hepatic reserve and tumorcharacteristics was confirmed as a risk factor for recurrence by multivariate analysis. To achieve longer disease-free survival, not only early detection but also suppression of co-existing hepatitis is prerequisite.