The epithelial damages of nasal mucosa in nasal allergy

1)嗜酸性粒细胞的颗粒蛋白最初通过微管在细胞质中被诱导，然后通过质膜的微破坏扩散到细胞外空间。随着嗜酸性粒细胞溶解程度的加深，大量颗粒物质释放到细胞外。2）鼻前粘膜上皮细胞损伤明显，表现为细胞间水肿或上皮脱落，鼻后粘膜上皮细胞损伤较轻。上皮损伤组和正常组迁移到上皮区的嗜酸性粒细胞总数无显著性差异。但上皮脱落严重的部位嗜酸性粒细胞的比例明显高于上皮完整的部位。3）前鼻粘膜上皮损伤明显，表现为明显的细胞间水肿或上皮脱落，后鼻粘膜上皮损伤较轻。上皮损伤组和正常组迁移到上皮区的嗜酸性粒细胞总数无显著性差异。但上皮脱落严重区的嗜酸性粒细胞溶解率明显高于上皮完整区。4）采血后，血清中嗜酸性粒细胞被破坏后释放出ECP，表明嗜酸性粒细胞易被破坏。

1) The granule proteins of eosinophils were initially induced in the cytoplasm via finetubles and then diffused in the extracellular space through micro-destruction of the plasma membrane. When the eosinophil lysis was advanced, a large amount of granule contents was released into the extracellular space.2) The epithelial damage, which was conspicuous intercellular edema or epithelial shedding, was found to be remarkable in the anterior nasal mucosae, but minor in the posterior nasal mucosae. The total number of the eosinophils which migrated to epithelial region was not significantly different between in the damaged epithelium and in the intact one. But the rate of cytolytic eosinophils was significantly higher in the area of severely shedded epithelium than in the area of intact epithelium.3) The epithelial damage which was conspicuous intercellular edema or epithelial shedding was found to be remarkable in the anterior nasal mucosae, but minor in the posterior nasal mucosae. The total number of the eosinophils which migrated to epithelial region was not significantly different between in the damaged epithelium and in the intact one. But the rate of cytolytic eosinophils was significantly higher in the area of severely shedded epithelium than in the area of intact epithelium.4) ECP in serum was released from destroyed eosinophils in test tube after the blood collection and it indicated the easiness of eosinophil destruction.