How Spinal Afferent Neurons Control Appetite and Thirst

该项目旨在提供关于肠道如何与大脑沟通的重要新见解，以调节食物和液体的消耗量。该提案预计将产生关于肠道-大脑通信的新知识，以及肠道的主要感觉神经之一如何传递有关口渴和食欲感觉的信息。该项目解决了依赖于我们实验室最近开发的技术的基本问题。我们希望证明一个主要的新的感觉神经通路从肠道到大脑，在食欲和口渴的感觉中起着重要作用。我们将学习当人们食用食物和饮料时，肠道与大脑的交流是如何成为“饱腹感”的基础的。

This project aims to provide major new insights about how the gut communicates with the brain, to regulate how much food and fluids have been consumed. The proposal expects to generate new knowledge about gut-brain communication and how one of the major sensory nerves from the gut relays information about thirst and appetite sensations. The project addresses fundamental questions that rely on techniques only recently developed in our laboratory. We expect to demonstrate a major new sensory nerve pathway from the gut to the brain that plays a major role in appetite and thirst sensations. We will learn how gut to brain communication underlies the feeling of "fullness" when people consume food and drink.