Morphological and functional study on relationship between jaw osteoporosis and masticatory status

1.去势大鼠下颌骨的基础研究结果雌激素缺乏可引起大鼠牙槽骨中骨小梁的增生性改变和牙槽骨本身的变薄。临床上应重视老年妇女牙周病和绝经后骨质疏松的状况，对抗牙的挤出导致咬合丧失，导致其牙槽骨高度增加。然而，内牙槽骨区的骨体积明显较低。此外，研究表明雌激素缺乏会导致严重的内骨丢失和牙槽骨上的骨小梁结构减弱，从而失去与拮抗牙的机械载荷，尽管它不影响牙槽骨高度.去卵巢猴下颌骨的基础研究结果去卵巢猴下颌骨的皮质骨和松质骨出现多孔性改变。特别是下颌骨皮质数据与腰椎骨质疏松密切相关。腰椎骨密度最低的受试者下颌骨骨密度最低，下颌骨和桡骨皮质多孔。因此，下颌骨皮质骨的信息似乎是有用的筛选严重骨质疏松症患者。人下颌骨骨密度的测量实验我们成功地测量了人下颌骨的骨密度，但测量表面的微小间隙很容易改变骨密度值。需要进一步改进以解决问题。

1. Results of fundamental research on ovariectomized rat mandibleEstrogen deficiency caused osteoporotic changes of trabecular bone and thin alveolar bone proper in rat alveolar bone. Clinically, we must pay more attention to the state of periodontal disease and postmenopausal osteoporosis in elderly women.The loss of occlusion caused by the extrusion of the antagonistic tooth resulted in an increase of its alveolar bone height. However, the bone volume of the internal alveolar area was significantly lower. In addition, it was demonstrated that estrogen deficiency caused severe internal bone loss and weakened trabecular bone structures on the alveolar bone that lost mechanical loading with the antagonistic tooth, although it did not affect alveolar bone height.2. Results of fundamental research on ovariectomized monkey mandibleThe ovariectomized monkey mandibles showed porotic changes in the cortical and trabecular bone. Mandibular cortex data in particular correlated closely with lumbar porosis. The subject whose lumbar bone mineral density was lowest showed the lowest mandibular BMD and had porous mandibular and radial cortices. Therefore, information on the mandibular cortical bone seems useful in screening severe osteoporosis patients.3. Trials of measuring the BMD of human mandibleWe succeeded to measure the BMD of human mandible, however, the BMD values were easily changed by only small gap of measuring surface. Further improvement is necessary to resolve the problems.