Analysis of Brain Function in Learning Process by Regional Cerebral Brood Flow

本研究的目的是发展和完善近红外光谱技术本研究利用近红外光谱（NIRS）技术，从局部脑血流量（rCBS）测量与学习功能相关的脑活动，通过了解实验数据与生理数据的关系，对学习过程进行测量和分析，并将该系统应用于学习情境中，研究了NIRS测量模型的构建、与fMRI的比较、本文报道了近红外光谱法（NIRS）在完成与学习有关的各种任务时，对大脑皮层氧合血红蛋白（OxyHb）和脱氧血红蛋白（DeoxyHb）浓度的测定，结果表明：（1）NIRS可在毛细血管水平上测定rCBF的变化。(2)oxyHb量的变化将反映在任务前/任务期间的个人表现上。(3)脱氧血红蛋白量的变化会反映在学习过程中。学习过程通常是通过行为表现来评价的，但本研究表明，近红外光谱方法可以定量地评价学习过程。现在，我们继续研究发现任务解决的时刻会伴随着脱氧血红蛋白量的斑点的假设。本研究表明，如果选择适当的探针位置，将获得较高空间分辨率。因此，我们认为，研究学习过程与脑功能的联系在教育中具有重要意义，因此，我们认为这项研究提出了基础性和重要的结果。

The purpose of this study is to development and improvement of NIRS(Near Infrared Spectroscopy) system to measure brain activity related to learning function from regional cerebral blood flow(rCBS) and to measurement and analysis of learning process through understanding relationship experiment data and physiological data, and application of this system into learning situation.Studies of construction of measurement model of NIRS, comparison with fMRI, measurement of oxy-hemoglobin(OxyHb) and deoxy-hemoglobin(DeoxyHb) concentration on cerebrum cortex in implementing various kinds of tasks which consider as association with learning have been done enthusiastically.The following results were obtained^*(1) It is suggested that NIRS could measure rCBF change on capillary level.(2) Change in oxyHb volume would be reflected on individual performance before/during tasks.(3) Change in deoxyHb volume would be reflected on learning process.Learning process is usually evaluated by behavior performance, however, this study suggested that the method of NIRS was useful for evaluate learning process quantitatively.Now, we continue to Investigate hypothesis that the moment of finding solution of tasks would be accompanies with spotting of deoxyHb volume.This study suggests that if selection of probe position is appropriate, high spatial resolution will be got. It is expected that investigation of the association learning process with brain function will be important in education, therefore, we believe that this study suggested fundamental and important results.