Investigating the Genetic Basis of Human Intrinsic Capacity

内在能力是世界卫生组织专家为促进健康老龄化而提出的一个新概念。它被定义为一个人的身体和精神能力的综合，基于五个标准的测量：认知，感觉，运动，活力和心理。这是一种遗传预定的特征，但受到一系列环境刺激的影响。该项目将尖端的遗传学方法应用于大型生物库数据集，旨在研究遗传学和环境的作用，以解释个体之间内在能力的差异。了解内在能力的生物学基础对健康老龄化和心理健康的科学研究具有重大意义。

Intrinsic capacity is a new concept introduced by experts at the World Health Organisation to promote healthy ageing. It is defined as the composite of an individual’s physical and mental capacities, based on measures of five criteria; cognitive, sensory, locomotor, vitality and psychological. It is a genetically predetermined trait, but is influenced by a range of environmental stimuli. Applying a cutting-edge genetic methodology on big biobank datasets, this project aims to examine the role of genetics and the environment to explain the variability of intrinsic capacity between individuals. Understanding the biological basis of intrinsic capacity has major implications for scientific research in healthy ageing and mental wellbeing.