Engineering micropatterned surfaces for cell mechanics and mechanobiology

该项目的目标是设计一种高度通用的微图案化表面，可用于培养和研究细胞。该项目希望通过阐明受控表面润湿性与细胞行为之间的关系，产生一种独特的微技术，以及表面科学和细胞力学方面的新知识。该项目的预期结果包括一种低成本和高度工程化的组织培养工具，它可以控制细胞功能，使干细胞工程实践发生革命性变化。该平台技术具有巨大的商业化潜力，并通过国际和跨学科合作提高澳大利亚的研究能力，并将直接使澳大利亚生物技术行业受益。

This project aims to engineer a highly versatile micropatterned surface that can be used to culture and study cells. This project expects to generate a unique microtechnology, as well as new knowledge in surface science and cell mechanics by elucidating the relationship between controlled surface wettability and cell behaviour. The expected outcomes of this project include a low-cost and highly engineered tissue culture tool that controls cellular functions, revolutionising practices in stem cell engineering. The platform technology has a great potential for commercialisation and enhancing Australian research capacity through international and interdisciplinary collaborations and will directly benefit the Australian biotech industry.