Spinal neuroplastic changes in lower urinary tract irritatioin, special reference to peripheral nerve growth factor and spinal protooncogene expression

1)膀胱、前列腺和外括约肌伤害性刺激后c-Fos表达的脊髓分布和血浆外渗的皮节分布具有相似性。在伤害性刺激下，这些器官的伤害敏感性传入通路具有相似性。2）慢性膀胱刺激引起脊髓P物质和NK 1受体免疫阳性区域的上调。慢性膀胱刺激后P物质-NK 1系统的传递上调。3）前列腺急性伤害性刺激导致脊髓P物质免疫反应性上调。这种增强通过施用α-阻断剂而减弱。P物质似乎在前列腺的伤害性传递中起重要作用。交感神经系统可能影响这种伤害性信息的传递。4）电刺激SI孔可以掩盖下尿路伤害性刺激后c-Fos的表达。骶神经刺激可能通过这种机制改善下尿路症状。

1) There was close similarity of spinal distribution of c-Fos expression and dermatome distribution of plasma extravasation after nociceptive stimulation of the bladder, prostate and external sphincter. Under the nociceptive stimulation , there would be close similarity in nocisensitive afferent pathways among these organs.2) Chronic bladder irritation induced upregulation of spinal substance P and NK1-receptor immuno-positive areas. Upregulation of transmission of substance P- NK1 system after chronic bladder irritation.3) Acute nociceptive stimulation of the prostate resulted in upregulation of spinal substance P immunoreactivity. This enhancement is weakened by administration of an alpha-blocking agent. Substance P appeared to play an important role in nociceptive transmission from the prostate. Sympathetic nerve system could influence such a nociceptive transmission.4) Electrical stimulation from the SI foramen could mask the c-Fos expression after nociceptive lower urinary tract stimulation. It appeared possible sacral nerve stimulation can improve lower urinary tract symptoms through this mechanism.