Basic Study for Health Control by Human Circadian Rhythm of Urinary Fluoride Excretion

研究了8名健康男性在禁食和喂养条件下的尿液排泄模式。禁食实验40小时不进食，随意饮水，喂养实验4天吃太空食品。在清醒时每隔2小时取尿样，测定F、Na、K、Cl、Ca、Mg、P和肌酐（Cre）。用余弦计算方法对结果进行生物节律分析。在禁食条件下，这些成分没有明显的生物节律。饲喂条件下，确定3个节律组：1组：Na、K、Cl；第二组：Ca、Mg、P、Cre；这些结果表明F和其他被研究的尿液成分之间的代谢行为有显著差异。

Fluoride (F) metabolism in eight healthy men was studied by urinary excretion patterns under fasting and feeding conditions. The subjects in the fasting experiment had no food for 40 hr and drank water ad libitum, while those in the feeding experiment ate space food for 4 days.Urine samples were taken at 2-hr intervals during waking hours for determination of F, Na, K, Cl, Ca, Mg, P, and creatnine (Cre). Results were analyzed for biorhythm by the cosinor computation method. Under fasting conditions, no biorhythm was apparent in these components. Under feeding conditions, three rhythm groups were identified : Group 1 : Na, K, and Cl ; Group 2 : Ca, Mg, P, and Cre ; and Group 3 : F. These results indicate marked differences in metabolic be-havior between F and the other urinary components under study.