The levels of cytokines and adhesion molecules in the placenta and blood in normal pregnancy and preeclampsia

胎盘组织巨噬细胞集落刺激因子(M-CSF值)/总蛋白(TP)比值正常妊娠组为96.3±2 1.6(U/mg蛋白，M±SD，n=19)，子痫前期组为115.6±2 9.0(n=18)。提示M-CSF可能与子痫前期的病理生理有关。正常妊娠组血清M-CSF值为1118U/m L(中位数，n=20)，宫内生长受限(IUGR)组为1322(n=27)。IUGR孕妇血清M-CSF水平明显升高。27例孕妇在剖宫产前、产后1天、产后10天分别采集外周血，其中12例为子痫前期患者，15例为正常血压孕妇。两组患者M-CSF水平在术后第1天显著升高，术后第10天显著下降。净增约270U/ml，两组升幅相近。研究了正常妊娠和子痫前期患者尿液中6项生化指标的排泄情况，明确了正常妊娠和子痫前期的肾脏生理和先兆子痫的肾脏病理生理，同时检测了正常妊娠和正常妊娠20、30、36周未孕妇女和正常妊娠妇女的止血五项指标和血管内皮状态。随着妊娠的进展，这些标志物的变化被阐明。

Macrophage colony-stimulating fector (M-CSF) values relative to total protein (TP) values in placental tissues were 96.3 ± 21.6 (U/mg protein, M ± SD, n=19) in normal pregnancies and 115.6 ± 29.0 (n=18) in preeclampsia Significant increases were seen in both blood M-GSF levels ard M-CSF/TP values in preeclampsia. These findings suggest that M-CSF may be related to the pathophysiology of preeclampsia. Serum M-CSF values were 1118 U/mL (median, n=20) in normal pregnancies and 1322 (n=27) in pregnancies with intrauterine growth restriction (IUGR). A significant increase in serum M-CSF levels was confirmed in pregnancies with IUGR. Elevated serum M-CSF levels may be related to placental hypoxia leading to pregnancies comphicated by IUGR.Peripheral blood was collected before, 1 day, and 10 days after cesarean section from 27 women, of whom 12 were preeclamptic patients and 15 were normotensive pregnant women. In two groups, the M-CSF levels increased significantry 1 day after surgery, but then decreased significatry 10 days after surgery. The increase was about 270 U/ml net and at similar levels in two groups. Thus, increases in M-CSF levels post-cesarean section may occur via similar mechanisms in two groups.Urinary excretion of six biochemical parameters was evaluated in normotensive pregnancy and preeclampsia Renal physiology in normotensive pregnancy and renal pathophysiology in preeclapsia were clarified.The levels of five markers of hemostasis and endothelial status were measured simultaneously in non-pregnant women and normotensive pregnant women in the 20th, 30th, and 36th week of gestation. Changes in these markers with progression of pregnancy were clarified.