Engineering of biocatalysis in metal-organic frameworks for CO2 conversion

将温室气体二氧化碳(CO2)转化为有价值的燃料将有利于缓解能源短缺，提高全球可持续性。该项目旨在构建一个金属-有机框架(MOF)中的生物级联系统，用于人工转化二氧化碳。从活的生物体中了解到，包括酶和辅因子在内的整个生物催化单元将被包裹在人造多孔聚合物MOF涂层中并受到保护。这种方法有望在涉及热、pH和化学应激源的工业操作条件下，提供具有高反应活性和化学选择性的生物催化剂，将二氧化碳转化为甲醇。这一进步将为碳中和行业和社会做出贡献。

Transforming the greenhouse gas carbon dioxide (CO2) into valuable fuels would be beneficial for relieving energy shortage and improving global sustainability. This project aims to architect a biocascade system in metal-organic frameworks (MOFs) for artificial CO2 conversion. Learned from the living organisms, a whole biocatalysis unit including enzymes and cofactors will be encased and protected in an artificial porous polymeric MOF coating. This approach is expected to deliver robust biocatalysts with high reaction-activity and chemo-selectivity in converting CO2 into methanol under the industrial operating condition, involving thermal, pH, and chemical stressors. This advancement will contribute to a carbon-neutral industry and society.