Quasi tissue engineering of Process for Fabrication of Multi-Functional Composites

随着社会老龄化，骨质疏松症等与骨骼相关的疾病逐年增多。根据卫生、劳动和福利部的调查报告，2010年被诊断为骨质疏松症的患者数量约为1250万，其中约80%是女性。因此，骨质疏松症可以被认为是日本面临老龄化社会的一种全国性疾病。在21世纪，对更高性能的人工骨将提出更高的需求。然而，对应用部件的要求可能会因骨骼而异，因为人体中的骨骼数量多达206个。替代人类硬组织材料所需要的功能不仅是生物相容性/生物亲和性，而且还包括高机械强度、高断裂韧性和低杨氏模数。本项目主要针对高负荷部件(髋关节)和低负荷部件(骨替代材料)的制造。在下面列出的当前主题中，主题(1)包括生物相容性和高负荷部件的制造，而主题(2)和(3)包括低负荷部件的制造：(1)涂层工艺和评价(2)自修复功能的形成过程(3)类骨复合材料的加工和评价

The number of diseases relating to the bones, such as osteoporosis, increases with aging in the society year by year. According to the report on an investigation of the Ministry of Health, Labor and Welfare, the number of patients who is diagnosed, as osteoporosis will be approximately 12.5 million in 2010 and approximately 80% are women among these patients. Thus the osteoporosis may be regarded as a national disease in Japan that faces the aging society.In the twenty-first century, advanced needs will arise for the higher performance artificial bones. The requirement for the applied parts, however, may be different from bone to bone, because the number of bones in the human body is as large as 206. The functions that are required to substitute the materials for human hard tissues are directed not only toward the biocompatibility/bioaffinity but also toward the high mechanical strength, high fracture toughness, and low Young's modulus. The present project is aimed at the fabrications of high loading parts (hip joints) and low loading parts (substitute materials for bones). Among the present subjects listed below, Subject (1) includes the fabrication of the biocompatible and high loading parts, whereas Subjects (2) and (3) include the fabrication of low loading parts :(1) Coating process and evaluation(2) Formation process of self-restoration function(3) Processing of bone-like composites and evaluation