Development of a simple and noninvasive method for measuring cerebral blood flow Tc-99m compounds and spectral analysis

脑血流量（CBF）的定量对于患者管理非常重要，特别是当存在脑血管疾病时。因此，本研究的目的是发展一种简单、无创的方法来测量CBF使用Tc-99 m化合物和光谱分析。2001年，我们开发了一套基于频谱分析的脑血流测量软件，并开始在正常志愿者中进行临床应用。我们分析了使用频谱分析测量的脑灌注指数（BPI）和使用正电子发射断层扫描（PET）测量的CBF之间的相关性，发现它们之间有很好的相关性。2002年，我们将我们的方法应用于脑血管疾病患者。在休息时和静脉注射1 g乙酰唑胺后测量BPI。还使用图形分析来测量BPI。所有患者均行H_2^<15>O PET检查，并将频谱分析法和图形分析法计算的BPI与PET测量的CBF值进行比较。我们发现，我们的方法产生一个更可靠的BPI比图形分析后乙酰唑胺CBF的定量。总之，我们的方法将是临床上有用的，因为它允许简单和无创的定量CBF，它是比传统的方法更可靠。

Quantification of cerebral blood flow (CBF) is very important for patient management, especially when cerebrovacular disease is present. Then, the purpose of this study was to develop a simple and noninvasive method for measuring CBF using Tc-99m compounds and spectral analysis. In 2001, we developed a software for measuring CBF using spectral analysis, and started its clinical application to normal volunteers. We analyzed the correlation between the brain perfusion index (BPI) measured using spectral analysis and the CBF measured using positron emission tomography (PET), and found that there was an excellent correlation between them. In 2002, we applied our method to patients with cerebrovascular diseases. The BPI was measured at rest and after the intravenous administration of 1 g of acetazolamide. The BPI was also measured using graphical analysis. In all Patients, an H_2^<15>O PET examination was performed, and the spectral analysis-calculated BPI and graphical analysis-calculated BPI were compared with the CBF values measured using PET. We found that our method yields a more reliable BPI than graphical analysis for the quantification of CBF after acetazolamide. In conclusion, our method will be clinically useful, because it allows simple and noninvasive quantification of CBF and it is more reliable than the conventional method.