The effect of hypocpnia and anesthetics on cerebral damage in a rat model of chronic cerebral hypoperfusion

慢性脑灌注不足大鼠脑白质病变具有特征性，是脑血管疾病的良好模型。过度换气引起的低碳酸血症引起了特定的进一步的尾核神经元损伤，氯胺酮预先给药可以改善这种损伤。这些结果表明，麻醉期间低碳酸血症可能导致尾丘核组织损伤，这可能是卒中和/或脑血管痴呆患者术后长期谵妄和/或记忆障碍的原因，而氯胺酮似乎有助于预防这种损伤。

White matter lesions are characteristic in a rat model of chronic cerebral hypoperfusion, which is a good model for patients with cerebrovascular diseases. Hypocapnia, induced by hyperventilation, caused specific further neuronal damage in the caudoputamen, which was ameliorated by ketamine pre-administration. These results suggest that hypocapnia during anesthesia may cause tissue damage in the caudoputamen, which may be responsible for long-lasting postoperative delirium and/or memory disturbances in patients with stroke and/or cerebrovascular dementia, and ketamine seems to be useful for preventing the damage.