Study of Lower Urinary Tract Dysfunction According to Aging Using Senescence Accelerated Mouse (SAM)

老龄组以雌性1岁SAM和2岁正常小鼠（无衰老加速症状）为老龄组，14周龄和1岁正常小鼠为对照组。在氨基甲酸乙酯麻醉下，聚乙烯管连接压力传感器和输液泵，通过穹顶插入膀胱。对照组小鼠14周龄与1岁正常小鼠各项指标均无差异。14周龄正常小鼠膀胱功能参数：排尿反射压力阈值为9.4 cmH2，膀胱顺应性为0.018ml/cmH2O，排尿时膀胱最大压力为36.9 cmH2O。在老龄组，1岁SAM小鼠与2岁正常小鼠之间无差异。在1岁的SAM中，膀胱功能参数如下；排尿反射压力阈值为36.3 cmH2O，膀胱顺应性为0.007 ml/cmH2O，排尿时膀胱最大压力为44.4 cmH2O。在不改变膀胱最大收缩压力的情况下，膀胱容量阈值较对照组明显升高，膀胱顺应性明显降低。这些数据表明，老年小鼠的膀胱传入系统和交感神经系统受到损伤

We studied the urodynamic problems according to aging using SAMFemale 1 years old SAM and 2 years old normal mice (without senescence accelerated symptoms from the same strain) were used as aged group, 14 weeks and 1 year-old normal mice were used as control group. Under urethane anesthesia, polyethylene tube connected to pressure transducer and infusion pump inserted into urinary bladder through the dome. Physiological saline was infused 0.02 ml/min and bladder pressure was monitored under single cystometric conditionIn control group, there was no difference in any parameters between 14 weeks old and 1 year old normal mice. In 14 weeks old formal mice, parameters for bladder function were following the pressure threshold for micturition reflex was 9.4 cmH2, bladder compliance was 0.018ml/cmH2O, maximum bladder pressure during voiding was 36.9 cmH2O.In aged group, there was no difference between 1 year old SAM and 2 years old normal mice. In 1 years old SAM, parameters for bladder function were following ; the pressure threshold for micturition reflex was 36.3 cmH2O, bladder compliance was 0.007 ml/cmH2O, maximum bladder pressure during voiding was 44.4 cmH2O. The volume threshold was significantly increased and the bladder compliance was significantly decreased from the control group without altering the maximum pressure of bladder contraction. These data suggested that afferent systems from the bladder and the sympathetic nerve systems were injured in aged mice