Studies on the Significance of Magnesium Metabolism in Physiological and Pathological Changes During Pregnancy

一、孕妇与非妊娠妇女镁代谢的比较发现：L)妊娠2、3、3孕期血清总镁水平显著低于非妊娠妇女和妊娠1、3、3孕期，血中离子镁水平在妊娠1、2、3、3、3、3、4、6、8、8、8、12、12、12、12、12、12、12、12、12、12、12、12、8、8、8、8、12、12、8、8、8、8、8、6、8、8、8、8、8、8、8、8、8、8、8、8、8、6、6、6、6、6、6、6、6、6、6、8、6、6、6、6、6、6、8、6、6、6、8、6、6、6、8、6、6、6、6、6、6、6、12、16、16、16、15、30、30、30、30、30、30、30、30、30、30、30天，血清总镁水平显著低于未孕妇女和妊娠1、4、3、3、3、4、4、3、4、4、5、4、4、5、5、6、3、3、3、6(3)非妊娠妇女黄体期血小板胞内镁浓度显著高于卵泡期。妊娠第1周仍高于黄体期，但第2、3孕期显著低于第1孕期。4)未孕妇女细胞内离子镁水平与血中离子镁水平呈负相关，而妊娠妇女则无此相关性。体外实验显示ES…妊高征组与正常妊娠组比较，1)血清总镁水平无明显差异，2)离子镁水平显著降低，3)细胞内镁离子水平显著降低，4)细胞内镁离子水平与平均血压呈显著负相关，5)尿镁排泄量显著高于正常妊娠组。体外实验表明，甲状旁腺素、内皮素和子痫前期患者的血清可降低细胞内镁浓度。III.用大鼠进行的实验揭示了促进钙的主动吸收的机制，钙是一种与镁类似的二价阳离子。在怀孕期间的十二指肠中，虽然没有这样的镁系统。提示妊娠期激素变化引起孕妇体内镁代谢改变，与正常妊娠相比，子痫前期患者存在镁相对缺乏状态。这种病理状态可能是维持病理生理状态较少的重要因素

I. Comparisons of magnesium metabolism in pregnant women with that in non-pregnant subjects revealed the following findings: l) serum total Mg levels in 2^<nd> and 3^<rd> trimester were significantly lower than those of non-pregnant women and in 1^<st> trimester of pregnancy, 2) ionized Mg levels in blood in 1^<st> trimester were significantly lower than those in non-pregnant women, followed by further declining in 2^<nd> and 3^<rd> trimester, 3) platelet intracellular Mg concentration in non-pregnant women in luteal phase was significantly higher than that in follicular phase. The value in 1^<st> trimester of pregnancy was still higher than that in luteal phase, although it significantly decreased in 2^<nd> and 3^<rd> trimester compared with that in 1^<st> trimester, 4) there was an inverse correlation between intracellular ionized Mg levels and ionized Mg in blood in non-pregnant women, while no such a relationship was observed in pregnant women. In vitro experiments revealed that es … More tradiol has an effect of reducing intracellular Mg ion and that progesterone has an effect of elevating that.II. Comparisons of magnesium metabolism in preeclampsia with that in normal pregnancy revealed that 1) there were no differences in serum total Mg levels, 2) ionized Mg levels were significantly lower, 3) intracellular Mg levels were significantly lower, 4) either intracellular Mg levels of ionized Mg or its blood levels showed significant inverse correlation with mean blood pressure, 5) urinary output of Mg was significantly higher. In vitro experiments showed that PTH, Endothelin and serum obtained from patient with preeclampsia lowered the intracellular Mg concentration.III. Experiments using rats revealed that there was a mechanism that augmented active absorption of calcium, a divalent cation just like Mg. In the duodenum during pregnancy, although there was no such a system for Mg. These results suggest that gestational hormonal changes bring altered Mg metabolism in pregnant subjects and that preeclampsia is affected with relative deficient state for Mg compared with normal pregnancy. This pathological state may be an important factor in maintaining the pathophysiology Less