Identification and analysis of a factor relevant to the promotion of endometrial cancer

雌激素除了对心血管系统和中枢神经系统起作用外，还可能对骨代谢起重要的功能调节作用。此外，雌激素作为雌激素的靶器官，在乳腺或子宫内膜的增殖和癌变中具有广泛的生理功能也是众所周知的。然而，这些细节是未知的。子宫内膜是雌激素易影响的器官之一。雌激素与乳腺癌、子宫内膜癌、子宫内膜增生症一样，是起中心作用的危险因素。对于临床使用研究，积极进行雌激素补充治疗，以预防和治疗绝经后骨质疏松症或缺血性心脏病（称为更年期障碍）。本研究从分子水平上解决了雌激素与细胞增殖和癌变的相关机制。从提取的RNA中分离出新的雌激素诱导基因，寻找子宫内膜生长因子，使癌基因在子宫内膜癌中的发现率降低，与新的雌激素诱导基因的关系尚不清楚。考虑到该实验结果，从使用DNA芯片方法提取的RNA中分离新基因的方法而不是通过传统的手工方法分离基因的方法是有效的，并且似乎是期望充分结果的分析方法。

Estrogen may play an important role also in functional regulation of bone metabolism besides cardiovascular system and central nervous system. Furthermore, estrogen having broad physiological function which in multiplication and canceration of mammary gland or endometrium for estrogen target organ is also well known. However these details are unknown. Endometrium easily influenced one of organ with estrogen. Estrogen is a risk-factor of playing the role central as breast cancer, endometrial cancer and endometrial hyperplasia. For clinical use studies, an estrogen supplement treatment positively performed for the prevention and the medical treatment purpose of osteoporosis or ischemic heart disease which are known as climacteric disturbance after a menopause. This research solved the mechanism related to cell multiplication and canceration of estrogen on the moleculer levels. The new estrogen induced gene was isolated from extracted RNA and searched for the endometrium growth factor.The rate of discovery of the oncogene in endometrial cancer was lowered and that relation with a new estrogen induced gene was not made clearly. Considering this experiment result, the method of isolated a new gene from RNA extracted using the DNA chip method rather than isolation of the gene by classical handmade method is efficient, and the analysis method by which sufficient result is expected is seemed.