BASIC AND CLINICAL RESEARCH OF MONITOR FOR NEUROPROTECTION

在视神经疾病中，自动视距测量已被用于监测视觉功能。估计青光眼患者的视野变化需要一年多的时间。倍频视距法（FDP）用于青光眼的筛查，可以检测青光眼的视野缺陷。FDP对青光眼的敏感性为98%，特异性为90%。我们研究了FDP作为青光眼的监测指标。青光眼患者经常规自动视距仪训练后，FDP有学习效果。FDP的第一个结果应该被删除以进行估计（Fujimoto et al, Am J Ophthalmol 2002）。随后的两次FDP测量由于疲劳导致敏感性降低（Zhang等人，Am J Ophthalmol 2003）。对侧眼严重受损的眼表现为相对过敏（Fujimoto et al, Am J Ophthalmol 2003）。FDP的短期和长期波动几乎与传统的自动视野检查相同（Minowa等人，千叶医学杂志，2003）。我们还没有获得内科和外科治疗的有用资料。

Automated perimetry has been used for monitoring visual function in optic nerve diseases. It takes over one year to estimate the change of visual field in glaucoma patients. Frequency doubling perimetry (FDP) has been developed for glaucoma screener and could detect glaucomatous visual field defects. FDP had 98% sensitivity and 90% specificity for glaucoma. We studied FDP as a monitor for glaucoma. The patients with glaucoma and well-trained by conventional automated perimetry showed a learning effect for FDP. The first results of FDP should be deleted for estimation (Fujimoto et al, Am J Ophthalmol 2002). Two consequent measurements with FDP produced decreased sensitivity due to a fatigue (Zhang et al, Am J Ophthalmol 2003). Eye with severely damaged contralateral eye showed relative hypersensitivity (Fujimoto et al, Am J Ophthalmol 2003). FDP had almost the same short- and long-term fluctuation as conventional automated perimetry (Minowa et al, Chiba Med J 2003). We have not obtain useful data for medical and surgical therapy.