Study on bone regeneration using an absorbable osteoconductive material with a jungle gym structure

我们可以通过用溶剂溶解来制造具有孔的聚乳酸（PLLA）片材。此外，我们还用溶剂将羟基磷灰石（HA）粉末粘附在PLLA表面，造成大鼠胫骨双皮质骨缺损。骨缺损用PLLA片或PLLA片粘附HA粉覆盖。分别于术后1、2、4周处死大鼠。胫骨连同周围组织一起切除。制备切片并用苏木精-伊红染色用于光学显微镜检查。结果，我们发现缺陷几乎恢复到原来的状态。在PLLA片粘附HA粉末的情况下，结果与PLLA片相同。在实验期间观察到一些炎症反应。PLLA在移植后4周内没有再吸收。总之，我们发现PLLA片有效地发挥了GBR膜的作用。

We could make a poly lactic acid (PLLA) sheet having a pore by dissolving with a solvent. Furthermore, we could adhere hydroxyapatite (HA) powder on the surface of the PLLA by a solventA bicortical bone defect in the tibia of the rat was made. The bone defect was covered with PLLA sheet or PLLA sheet adhering HA powder. The rats were killed at 1,2 and 4 weeks after surgery. The tibia was excised with surrounding tissue. Sections were prepared and were stained with hematoxylin-eosin for light microscopy. Consequently, we found that the defect was restored to nealy original condition. In the case of PLLA sheet adhering HA powder, the result was the same of PLLA sheet. A few inflammatory reaction was observed during the experimental periods. PLLA was not resorbed at four weeks after implantationIn conclusion, we found that PLLA sheet functioned effectively as a GBR membrane