Studies of data-collecting strategies for the literature database on diagnostic characteristics of laboratory examination and structural design of the database

为了更有效地进行检验医学系统评价，对与诊断准确率有关的文献检索策略和数据库结构进行了研究。利用MEDLINE检索文献，识别已发表的系统评价文章时，根据MESH、副标题、正文等关键词使用的不同，其识别率有很大差异。因此，在系统回顾中，为了在不忽视的情况下进行高度敏感的检索，需要根据Haynes等人研究的检索结果，仔细考虑“敏感性*”、“特异性*”、“诊断试验*”等检索词的组合以及诊断试验本身的命名。此外，作为系统评价数据库的结构，认为该数据库由以下部分组成是合适的：主要文章的文献信息、关于Sys…的摘要信息在数据库结构的基础上，开发了具有Web界面的知识库，以便通过研究人员的协作行动有效地和持续地进行系统评价，并安装了以下功能：1)显示已被批判性评价的文章；2)在数据库上登记研究报告的文献信息页面和用于批判性评价的页面；3)用于输入诊断特征的页面和自动计算保密间隔的功能；4)用于基于组的系统评审的输入/输出页面；5)荟萃分析和图表的信息提取(森林图和总结ROC曲线)：以及6)注册未发表研究的页面和编辑摘要的页面。本课题组成员和其他协作评价者将数据录入该数据库，对系统的完整性进行评价，减少了对系统的上报

The search strategy in identification of the articles related to diagnostic accuracy and a structure of database were investigated for performing systematic review in laboratory medicine efficientlyWhen retrieval of article from MEDLINE was performed to identify articles listed in published systematic reviews, the rate of identification of them varied greatly according to the difference in usage of keyword such as MeSH, subheading term or text words. Therefore, in systematic review, in order to perform highly sensitive search without an overlooking, careful thinking for combination of searching terms such as "sensitiv*", "specificit*", "diagnos*" and nomenclature of diagnostic test itself was required based on the result of retrieval investigated by Haynes and others. Moreover, as the structure of a database for systematic review, the database consisting of the following components was considered as suitable : literature information of primary articles, information about summary of sys … More tematic review, additional information on the quality and external validity of literature, diagnostic accuracy, and index information such as MeSHBased on the database structure, knowledge database with Web interface was developed in order to perform systematic reviews efficiently and continuously through collaborative actions by researchers and the following functions were mounted : 1) displaying articles that have been appraised critically ; 2) a page for registration of literature information of study reports on the database and a page for critical appraisal ; 3) a page for entry of diagnostic characteristics and a function of automatic calculation of confidential intervals ; 4) an input/output page for group-based systematic review ; 5) extraction of information for meta-analyses and graphs (Forest plot and summary ROC curves) : and 6) a page for registration of unpublished studies and a page for editing abstracts. Moreover, the check list for critical appraisal was improved according to the differences between the previous one and other tools such as STARD initiativeMembers of our study group and other collaborative reviewers entered data into this database to evaluate the integrity of the system and reported the system Less