Release control of cyclodextrin intercalated hydrotalcite

以DDS为主体，考察了SBE 7-β-环糊精对水滑石的插层作用。通过改变SBE 7-β-环糊精水溶液的浓度，得到不同插层量的均一插层化合物，并采用两种方法将药物引入环糊精空腔，即（1）在水溶液中将药物包合到环糊精中，然后将药物包合到环糊精中，（2）SBE 7-β-环糊精插层水滑石对药物的直接包合。通过改变SBE 7-β-环糊精水溶液和溶剂的浓度，可调节包合药物的量，并考察了所得化合物在水和JPXIII 2液中的释放特性<nd>。释放曲线依赖于环糊精的摄取量。特别是SBE 7-β-环糊精插层水滑石，在4 mmol/g水滑石的吸附量下，具有明显的缓释效果。

Intercalation of SBE7-β-cyclodextrin into hydrotalcite was examined aiming for DDS host. By changing the concentration of SBE7-β-cyclodextrin aqueous solution, uniform intercalation compounds with different amount of intercalated SBE7-β-cyclodextrin were obtained.Two methods were used for the introduction of drug in the cyclodextrin cavity, that is, (1)inclusion of drug in cyclodextrin in aqueous solution and then the intercalation of drug included cyclodextrin, (2)inclusion of drug directly into SBE7-β-cyclodextrin intercalated hydrotalcite. At that time the amount of included drug could be regulated by changing the concentration of SBE7-β-cyclodextrin aqueous solution and solvents.Release profiles into H_2O and JP XIII 2^<nd> fluid were examined for the obtained compounds. Release profile depended on the uptake amount of cyclodextrin. Especially, delayed release profile was obtained for SBE7-β-cyclodextrin intercalated hydrotalcite with the uptake amount of 4 mmol/g of hydrotalcite.