Genetics of Atrial Fibrillation in the Framingham Heart Study. Population in Primary Prevention

心房颤动（AF）是最常见的致残性心律失常导致中风和心力衰竭。尽管其在现代人口中日益增加的社会经济相关性，但有关易感风险因素和触发因素的数据很少。弗雷明汉心脏研究（FHS）是世界各地在预防心脏病方面取得显著进展的代名词。直接解决的研究问题将是房颤的患病率和发病率。研究设计允许在遗忘、环境、临床和心电图因素的背景下，对最初健康个体的房颤遗传学进行全面研究。为了研究与房颤风险相关的遗传因素，选择了补充方法；A)检查炎症和心脏重塑途径的候选基因；b)最重要的是，将使用100K（可能是550 K）基因组扫描进行全基因组关联研究；c)最后建立AF发生风险的预测模型。在返回德国美因茨约翰内斯古登堡大学的prevention -it研究中，将对获得的遗传数据进行复制和验证，这是一项基于人群的前瞻性研究，包括1.7万名德国人，提供临床、遗传和蛋白质组学参数。

Atrial fibrillation (AF) is the most common disabling cardiac arrhythmia leading to stroke and heart failure. Despite its increasing socioeconomic relevance in a modern population data on predisposing risk factors and triggers are scant. The Framingham Heart Study (FHS) is synonymous with the remarkable advances made in the prevention of cardiac disease throughout the world. Directly addressed research questions will be the prevalence and incidence of AF. The study design allows a comprehensive research of the genetics of atrial fibrillation in initially healthy individuals in context with anamnestic, environmental, clinical, and electrocardiographical factors. To investigate the genetic factors associated with AF risk complementary approaches are chosen; a) candidate genes of inflammatory and cardiac remodelling pathways are examined; and b) - most importantly - genome wide association studies using 100K (potentially 550 K) genome scans will be applied; c) finally a prediction model for the risk of developing AF will be developed. Replication and validation of the obtained genetic data will be performed after return to Germany in the PREVENT-it Study, Johannes Gutenberg-University, Mainz, a population-based prospective study comprising 17.000 German individuals providing clinical, genetic, and proteomic parameters.