Logistic strategy for molecule-targeting therapy in brain tumors

脑肿瘤治疗管理的确定基于个体患者的宿主因素和肿瘤因素。为了研究脑膜瘤的体内转运系统和肿瘤增殖，采用~（16）<18>F-氟脱氧葡萄糖（FDG）或~（16）<18>F-氟硼苯丙氨酸（F-FDG）进行动力学分析，并与血管内皮生长因子（VEGF）和葡萄糖转运蛋白-1（Glut-1）的免疫反应性进行比较。K1在脑膜瘤中高于胶质瘤，在非典型脑膜瘤中高于良性脑膜瘤。在脑膜瘤中，k3与增殖指数MIB-1 LI相关。免疫组化显示，脑膜瘤对VEGF或Glut-1的反应性低于胶质瘤，但非典型脑膜瘤的染色强度高于良性脑膜瘤。K1和K3的高值表明脑膜瘤的侵袭性增殖， ...更多信息 在典型的脑膜瘤中，高渗透性和大表面积的协同作用为葡萄糖代谢和肿瘤增殖提供了有利条件，FDG的摄取和分布是肿瘤恶性程度和肿瘤范围的重要标志。包括峰值FDG摄取部分的肿瘤部分是用于准确诊断恶性肿瘤的目标。高级别胶质瘤显示异质性摄取模式，反映了由聚集的肿瘤细胞、坏死和瘤周水肿组成的细胞组成的地形变化。在大多数良性肿瘤中，如脑膜瘤和中枢神经细胞瘤，非典型亚型有相对较高的FDG摄取。最大限度地减少肿瘤的质量，当不典型的。目前的研究表明，后勤支持因素促进肿瘤的生长，包括肿瘤血管生成。功能影像的临床应用可以提供多学科的生物学特征，并根据肿瘤因素进行更适当的治疗，并可能导致延长脑肿瘤的高水平性能状态。少

Determination of therapeutic management of brain tumors is based on both host factors of individual patients and tumor factors. Current development in functional neuroimaging such as PET characterizes in vivo tumor factors including physiological and biochemical process of brain tumors.To test in vivo transport system and tumor proliferation of meningiomas, kinetic analysis using ^<18>F-fluorodeoxyglucose (FDG) or ^<18>F-fluoroboronophenylalanine-was obtained and compared with immunoreactivity to vascular endothelial growth factor (VEGF) and glucose transporter-1 (Glut-1). K1 was higher in meningiomas than in gliomas, and was higher in atypical than in benign meningiomas. k3 was correlated with a proliferating index, MIB-1 LI, in meningiomas. Immunohistochemically, meningiomas were less reactive to VEGF or Glut-1 than gliomas, but atypical meningiomas stained more intensely than benign meningiomas. High values for K1 and k3 indicate the aggressive proliferation of meningiomas, and in a … More typical meningiomas, the synergistic interaction of the high permeability and the large surface area yielded conditions conducive to glucose metabolism and tumor proliferation.The uptake and distribution of FDG is important landmark for malignancy and tumor extent. The tumor portion including a peak FDG uptake portion is a target for accurate diagnosis of malignancy. High-grade gliomas show heterogeneous uptake patterns, reflecting a topographic variation of cellular composition consisting of aggregated tumor cells, necrosis, and peritumoral edema. Among mostly benign tumors such as meningioma and central neurocytoma, atypical subsets have a relatively high uptake of FDG. The maximum reduction of tumor mass may be applied, when atypical.The present study indicates that logistic support factors enhance tumor growth including tumor angiogenesis. Clinical use of functional image less invasively provides multidisciplinary biologic characteristics and leads to more appropriate treatment based on the tumor factors, and may result in prolonging high levels of performance status in brain tumors. Less