Assembling Database of Minute Surface Structure and Genetic Analysis of Amelogenesis Imperfecta in Asia

2006年3月在北京大学召开了中国牙医师和研究人员关于牙釉质形成的研讨会。吴南博士是北京大学医院的中国牙医师和研究员，于2006年4月进入九州大学牙科科学研究生院。他在野中教授和福本副教授的指导下开始了遗传分析的研究。我们的合作者之一葛立宏教授在中国发现了家族性的牙釉质发育异常。在四代22人的家庭中，有10人发生了釉质发生性牙釉质发育障碍。我们对这些家庭中的18名活着的人进行了口腔检查并拍摄了口腔照片。在获得他们的同意后，我们从其中一些人身上采集了血液样本，并将其低温保存在北京大学。我们对4名患儿进行了印模，并制作了两套石膏模型。吴南博士将其中一个模型带到我校，并开始用非接触式激光扫描仪测量微小表面结构。我们在北京大学医院照顾病人。我们遵守北京大学的道德规范。2006年11月，我们与北京大学的合作者组成的研究小组赴新疆医科大学，在日本召开了关于儿童牙釉质发育和儿童牙科治疗现状的研讨会。我们让他们找一个牙釉质发育不全的病例。

We held the symposium in regard to amelogenesis imperfecta for Chinese dentists and researchers at Beijing University in March, 2006.Dr.Wunan, who was a Chinese dentist and researcher at Beijing University Hospital, entered graduate school of Dental Science, Kyushu University in April,2006. He has started to research genetic analysis under Professor Dr.Nonaka and Associated Professor Dr.Fukumoto.The familial case of amelogenesis imperfecta was detected in China by Professor Ge Li-Hong, who is one of our collaborators. Ten people had an onset of amelogenesis imperfecta among families of 22 people over four generations. We performed oral examinations and took oral pictures of alive 18 people among the families. We took blood samples from some of them after gaining their approval, and kept them cryogenically at Beijing University. We took impressions of affected 4 children, and made two sets of plaster models. Dr.Wunan brought one of the models to our University, and started to measure the minute surface structure by non-contact laser scan device. We are taking care subjects at Beijing University Hospital. We conformed to ethical code of Beijing University. One of our collaborators at Beijing University is making some of results as a master's thesis.In November,2006,our research team who consisted of both Japanese and Beijing University had been to Xinjiang Medical University located west China, and held symposium in regard to amelogenesis imperfecta and current dental treatment for children in Japan. We asked them to look for the case of amelogenesis imperfecta.