Basic study in effectiveness and safety of liquid ventilation for severe respiratory failure

液体通气（LV）的概念在过去的三十年里得到了广泛的研究。许多研究已经评估了全氟碳液体在肺损伤情况下增强气体交换和肺功能的能力。气体通风和液体通风的气体交换机制有很大的不同。然而，关于液体通气中最大气体交换和肺功能的通气设置的研究很少。在本研究中，我们对大鼠模型液体通气的电学和安全性进行了基础研究。首先，分析了不同操作条件下（分气量：167、200、267 mL/min，呼吸频率：40、50、60、70、80、90 /min， I: E: 1:2、1:1），气体通气和部分液体通气之间的P_aCO2和P_aO2。其次，在大鼠模型中比较了气体通气和部分液体通气对气体交换和肺功能的影响。结果表明，液体通气时通气设置对肺功能和气体交换的影响大于气体通气。我们认为，在重症呼吸衰竭患者进行液体通气治疗时，应密切监测气体交换和肺功能如P_aCO2和P_aO2。

The concept of liquid ventilation (LV) has been investigated over the past three decades. Numerous studies have evaluated the ability of perfluorocarbon fluids to enhance gas exchange and pulmonary function in the setting of lung injury. The mechanism of gas exchange is quite different during between gas ventilation and liquid ventilation. However there are very few studies to investigate the setting of ventilation to maximum gas exchange and pulmonary function during liquid ventilation. In this study, we performed a basic study for electiveness and safety of liquid ventilation in a rat model First, P_aCO2 and P_aO2 were analyzed during between gas ventilation and partial liquid ventilation in the various operational conditions (minute volume: 167, 200, 267 mL/min, respiratory rate: 40, 50, 60, 70, 80, 90 /min, I : E : 1 : 2, 1 : 1). Second, the effect of ventilation settings to gas exchange and pulmonary function were compared during between gas ventilation and partial liquid ventilation in a rat model. It was revealed that the effect of ventilation settings to gas exchange and pulmonary function during liquid ventilation is larger than during gas ventilation. We conclude that gas exchange and pulmonary function such as P_aCO2 and P_aO2 should be monitored carefully during liquid ventilation in the treatment of the patients with severe respiratory failure.