A community-based study of the relationship between behavioral job characteristics and stroke

一项基于社区的多地点队列研究进行了检查行为工作特征与卒中发病率和全因死亡率之间的关系。研究对象是居住在日本12个直辖市的6,509名工人（3,331名女性和3,178名男性）。年龄范围为45-65岁。运用Karasells需求控制模型对工作特征进行评价。基线数据和书面同意是在1992-1995年获得的。这些研究对象被跟踪到2002年。平均随访时间为9年。使用硬币比例风险模型估计全因死亡率的相对风险。hr计算参照的是低要求高控制的亚组，数据分析按性别进行。年龄、人口统计学因素和经典心血管危险因素（血压、总胆固醇和葡萄糖耐受不良）被用作分析中的协变量。在这期间，157名男性和64名女性死亡。在男性中，高要求和高控制（主动工作）亚组的HR显著降低（0.53；95%可信区间- 0.31,0.89）。这一结果主要源于该亚组的低癌症死亡率。在心血管死亡率和意外死亡方面没有观察到显著差异。在女性中，没有获得显著的解释性结果。总之，积极的工作环境可以降低男性全因死亡率的风险

A multisite community based cohort study was performed to examine the relationship between behavioral job characteristics and stroke incidence and all cause mortality. Subjects were 6,509 workers (3,331 women and 3,178 men) who lived in 12 municipalities in Japan. The range of age was 45-65 years. The job characteristics were evaluated by the Karasells demand control model.Baseline data and written consents were obtained in 1992-1995. The subjects were followed up to 2002. The mean follow up duration was 9 years. Coin proportional hazard model was used to estimate relative risks for all cause mortality. Reference for the HRs calculation was a subgroup categorized as having low demand and high control Data analysis was performed by sex. Age, demographic factors and classical cardiovascular risk factors (blood pressure, total cholesterol, and glucose intolerance) were used as covariates in the analyses.During the years 157 men and 64 women died. In men, subgroup with high demand and high control (active job) showed significantly lower HR (0.53; 95% confidence interval- 0.31, 0.89). This result derived mainly from low cancer mortality in the subgroup. No significant differences were observed in cardiovascular mortality and accidental death. In women, no significantly interpretive results were obtained.In conclusion, the active job circumstance for men could reduce the risk of all cause mortality