Study on molecular basis of expression and structure of complement component C1s/C1r/C1r-LP

补体成分C1 s、C1 s和C1 r-LP的人类基因紧密位于12号染色体上，并且在结构上彼此相似。C1 S/C1 R基因由共同的祖先基因产生，C1 r-LP基因由C1 R基因重复产生。本研究阐明了非人灵长类C1 S和C1 R基因的编码外显子结构，并表明在基因复制后，每个基因在灵长类中经历了相似的进化速率。

The human genes for complement components C1s,C1s and C1r-LP are closely located on chromosome 12 and are structurally similar to each other. C1S/C1R genes were generated from a common ancestral gene and C1r-LP gene was generated by C1R gene duplication. In this study, we clarified the coding exon organization of non-human primate C1S and C1R genes, and it was shown that each gene has gone through a similar evolutionary rate in primate after gene duplication.