Role of dbpA in hepatocarcinogenesis

我们认为dbpA是连接慢性炎症和癌变的候选分子。在2006年和2007年接受援助款时，我们明确了以下五点。dbpA在肝细胞癌（HCC）中的表达与邻近非HCC组织中dbpA启动子甲基化相关。在dbpA转基因小鼠的肝脏中，加速细胞增殖的细胞基因表达增强，甚至在此之前。肝脏发生形态学改变。缺血应激诱导大鼠肝脏中dbpA的表达。在体外，短暂过表达dbpA可加速培养细胞的增殖。在高分化胃癌组织中，dpbA的表达定位于管状结构底部。这表明，在高分化胃癌中，分裂细胞位于管状结构的底部，就像在正常胃粘膜的隐窝底部一样。这一发现还表明，dbpA可能是癌症干细胞的标记物。

We consider dbpA to be the candidate molecule which connects the chronic inflammation and carcinogenesis. In 2006 and 2007 when we received Grant-in-aid (C), we clarified the following five points.1. Expression of dbpA in hepatocellular carcinoma (HCC) was associated with the dbpA promoter methylation in the adjacent non-HCC tissues.2. In the liver of dbpA transgenic mice, expression of cellular genes accerelating the cell proliferation was enhanced, even before the stage when the .morphological liver change occurred.3. The ischemic stress induced expression of dbpA in the liver.4. In vitro, transient overexpression of dbpA accerelated the proliferation of cultured cells.5. In the well-differentiated stomach cancer tissue, the expression of dpbA was localized in the bottom of the tubular structures. This finding suggested that, in well-differentiated stomach cancer, the dividing cells are located in the bottom of the tubular structures, as if in the bottom of crypt in normal gastric mucosa. The finding also suggested the possibility that dbpA might be the markers of canncer stem cells.