Real-time imaging of inflammatory reactions and their related metabolic factors in vivo

在本研究中，我们建立了一种新的活体显微系统，用于分析白细胞在体内向受损小鼠股动脉的募集。我们发现白细胞中的氧化应激在炎症的发展中起着重要作用。此外，我们的观察点在这个过程中的重要作用，肾素-血管紧张素系统。至于代谢综合征对动脉粥样硬化的作用，我们报道了抑制肠道脂质吸收可以减少肝脂肪变性和随后的胰岛素抵抗。我们的研究结果大大提高了动脉粥样硬化和代谢综合征的知识与各种未来的临床应用。

In this project, we established a novel intravital microscopic system to analyze leukocyte recruitment to the injured mouse femoral artery in vivo. We found that oxidative stress in leukocytes plays a major role in the development of the inflammation. Further, our observation points an important role for renin-angiotensin system in this process. As for the contribution of metabolic syndrome to atherosclerosis, we reported that inhibition of intestinal lipid absorption reduced hepatic steatosis and subsequent insulin resistance. Our results greatly enhance the knowledge of atherosclerosis and metabolic syndrome with various future clinical applications.