Modulation of cellular metabolism based on controlling the mobility of multivalent ligands using stimuli-responsive polyrotaxanes

为了通过刺激响应性聚轮烷来控制细胞反应，进行了各种聚轮烷的制备、其性质的表征以及对这些聚轮烷的蛋白质和细胞反应。在这项研究中，阐明了松散的聚轮烷，温度响应性聚轮烷的形成，甘露糖结合的聚轮烷与特定蛋白质的结合增强，以及巨噬细胞产生抗炎细胞因子的大分子包含。

In order to aim at controlling cellular response via stimuli-responsive polyrotaxanes, the preparation of a variety of polyrotaxanes, the characterization of their properties, and the protein and cellular responses to these polyrotaxanes were performed. Macromolecular inclusion of loose-fit polyrotaxane, temperature-responsive polyrotaxane formation, enhanced binding of mannose-conjugated polyrotaxane with specific protein, and the production of anti-inflammatory cytokine from macrophages were clarified in this study.