Mesenchymal stem cells dynamism in microgravity environment.

微重力环境扩大了维持未分化状态的间充质干细胞群。我们发现微重力环境导致与细胞骨架蛋白相关的肌动蛋白丝聚合减少，并减少了焦点接触的数量。微重力环境下未分化的细胞由于受到物理刺激而从细胞表面进入细胞核的信号减少，基因表达发生改变。在微重力环境下，考虑了培养过程中端粒的长度。

Microgravity environment expand mesenchymal stem cells populations that were maintained undifferentiated state. We showed microgravity environment caused polymeric decreased actin filament related to cytoskeleton proteins and decrease of number of focal contacts. Undifferentiating cells in microgravity environment as a result that decreased of signal by physical stimulation from the cell surface into a nucleus, and gene expression changed. Telomere length remained during culturing was considered in microgravity environment.