Mesenchymal stem cells dynamism in microgravity environment.

微重力环境对维持未分化状态的间充质干细胞群体进行扩增。我们发现，微重力环境导致与细胞骨架蛋白相关的肌动蛋白微丝聚集性减少，焦点接触数减少。微重力环境下细胞未分化的结果是物理刺激使信号从细胞表面进入细胞核而减少，基因表达发生变化。在微重力环境下考虑培养过程中保留的端粒长度。

Microgravity environment expand mesenchymal stem cells populations that were maintained undifferentiated state. We showed microgravity environment caused polymeric decreased actin filament related to cytoskeleton proteins and decrease of number of focal contacts. Undifferentiating cells in microgravity environment as a result that decreased of signal by physical stimulation from the cell surface into a nucleus, and gene expression changed. Telomere length remained during culturing was considered in microgravity environment.