Relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress

本研究旨在阐明黄酮类化合物的代谢转化与其氧化应激控制功能之间的关系，利用槲皮素，一种广泛存在于水果和蔬菜中的抗氧化黄酮。结果表明，结合槲皮素代谢产物通过活化的巨噬细胞样细胞解结合后发挥强大的抗氧化活性。这可能是膳食黄酮有助于抑制氧化应激发生在内膜和中枢神经系统的目标网站在应激负荷状态下转化为他们的苷元。

This study was aimed to clarify the relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress control using quercetin, an antioxidative flavonoid ubiquitously present in fruits nad vegetables. The results indicate that conjugated quercetin metabolites exert a powerful antioxidant activity after deconjugation via activated macrophage-like cells. It is likely that dietary flavonoids are helpful in the suppression of oxidatives stress occurring in the target sites of intima and CNS by converting to their aglyone under stress-loaded state.