Neuropathogenesis of retrovirus infection : diverse in vivo and ex vivo analysis of HAM/TSP and AIDS encephalopathy.

为了阐明逆转录病毒引起的神经系统疾病的神经发病机制，我们对HAM/TSP和AIDS脑病进行了不同的体内和体外分析。我们证实在HAM/TSP的炎性病变中存在感染的单个核细胞和病毒特异性细胞毒性T淋巴细胞的聚集。关于艾滋病脑病以及HTLV-1相关性多发性肌炎的更多研究表明，被感染的单个核细胞侵入神经系统部位并对这些被感染细胞进行免疫反应是逆转录病毒诱导的神经疾病的常见致病过程。我们还证明，在艾滋病脑病中，大脑皮层的变性独立于炎症过程而发生，星形胶质细胞的功能障碍可能在这一退化过程中起作用。

In order to clarify neuropathogenesis of retrovirus-induced neurological disorders we performed diverse in vivo and ex vivo analysis of HAM/TSP and AIDS encephalopathy. We demonstrated presence of infected mononuclear cells and accumulation of virus-specific cytotoxic T lymphocytes in the inflammatory lesions of HAM/TSP. Additional studies on AIDS encephalopathy, as well as HTLV-1-associated polymyositis, suggest that invasion of infected mononuclear cells in the site of the nervous system and immune responses against these infected cells is a common pathogenic process of retrovirus induced neurological disorders. We also demonstrated that degeneration of the cerebral cortex occurs in AIDS encephalopathy independently from the inflammatory process, and dysfunction of astrocytes may have a role in this degenerative process.