Elucidation of brain morphological change and functional change at risk mental state

我们的调查显示，精神分裂症患者不同脑白质区域的FA较低，这意味着脑白质完整性的破坏。在病例组中，胼胝体前部FA值与阴性症状的严重程度呈负相关。在这项使用基于体素的扩散张量成像的研究中，与首发精神分裂症患者相比，ARM有轻微的脑部结构变化。这一发现归因于这样一个事实，即ARM包括了那些有精神病前兆的人，他们后来发展成精神病，但没有。我们用手动追踪法进行的纵向研究显示，精神分裂症患者在疾病的早期表现出与明显的精神病相关的进行性灰质减少。

Our investigation revealed lower FA in various white matter regions that implies the disruption of white matter integrity in schizophrenia patients. In the patient group, the FA value of the anterior part of the corpus callosum was negatively correlated with the severity of negative symptoms. In the study using the voxel-based diffusion tensor imaging, ARMS had mild structural brain change compared to first episode schizophrenia patients. This finding was ascribed to the fact that ARMS included people with prodromal signs of psychosis who developed psychosis later and had not. Our longitudinal study with manual tracing method, schizophrenia patients exhibit progressive gray matter reductions associated with overt psychosis in the early years of the illness.