A novel strategy of prevention of gastric cancer recurrence-prediction of effect of chemotherapy for potential recurrence after curative operation-

多因素分析显示，淋巴结转移阳性、总胆固醇水平低、淋巴细胞数量少、静脉侵犯阳性、血清CA19-9水平升高是影响胃癌根治术后患者预后的独立因素。在这种情况下，应该考虑使用抗癌药物。此外，评价5-FU代谢酶的活性可能有助于预测胃癌患者的抗癌药物疗效和预后。

Multivariate analysis identified positive lymph node metastasis, low total cholesterol level, a small number of lymphocytes, positive venous invasion, and elevated serum CA19-9 level as independent prognostic factors in curatively resected gastric cancer patients. It should be considered to administer anti-cancer drugs in such cases. In addition, it may be useful to evaluate enzyme activity regarding 5-FU metabolism in predicting the effect of anticancer drugs and prognosis of gastric cancer patient.