Immunological evaluation and prediction of the effectiveness of interferon therapy for the Japanese multiple sclerosis patients

(1)继发性进行性多发性硬化（SPMS）具有正常的调节性T细胞功能，因此SPMS具有少量克隆扩增的致病性T细胞。Neuromyoptica表达的结果与SPMS完全相反。日本多发性硬化症患者必须根据其分类类型选择适当的治疗。(2)日本多发性硬化症患者的早期干扰素治疗可抑制复发次数和MRI病变。此外，它还有助于维持患者的生活质量。(3)由于继发性进行性视神经肌萎缩症患者存在炎症和脱髓鞘，因此不能用干扰素治疗。

(1) Secondary progressive multiple sclerosis (SPMS) had a normal function of the regulatory T cells, therefore SPMS had a small number of clonally expanded pathogenic T cells. Neuromyelitis optica expressed results exactly the opposite of SPMS. Japanese multiple sclerosis patients must choice the appropriate therapy according to their classified type.(2) Early interferon therapy for the Japanese multiple sclerosis patients suppresses the number of relapse and the MRI lesions. Moreover, it effect to sustain the quality of life for the patients.(3) Because the secondary progressive neuromyelitis optica patients reveal the inflammation and demyelination, they must not be treated with interferon.