Research on development of hyper IgE and dermatitis through Ttc7, the regulatory factor of an autoinflammatory disease

由于和歌山医科大学动物设施SPF区的MHV污染，使用FSN小鼠进行的体内和体外实验尚未获得足够的结果。BALB/c-FSN小鼠与C57BL/6小鼠进行了回交，没有发现任何明显的表型。另一方面，对人类慢性皮炎的SNP分析表明，TTC7A基因的一种特定单倍型与牛皮癣之间存在微弱但显著的关联，而不是特应性皮炎。

Sufficient results have not been obtained by in vivo and ex vivo experiments using fsn mice, owing to MHV pollution in the SPF areas of the Wakayama Medical University Animal Facilities. Backcrossing BALB/c-fsn mice with C57BL/6 mice has been performed without revealing any obvious phenotype. On the other hand, the SNP analyses on human chronic dermatitis have shown a weak but significant association of a particular haplotype of the Ttc7a gene with psoriasis, rather than atopic dermatitis.