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Influence of abnormal body temperature on expression of mucin in the respiratory tract under the artificial respiration Hyperthermia vs hypothermia-

Influence of abnormal body temperature on expression of mucin in the respiratory tract under the artificial respiration Hyperthermia vs hypothermia-
人工呼吸条件下体温异常对呼吸道粘蛋白表达的影响
批准号:
19791072
负责人:
HASEGAWA Akira
金额:
$2.38万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

项目摘要

项目成果

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中文摘要
翻译
炎症使呼吸道黏液蛋白增加,但不清楚黏液蛋白的表达是否受到体温异常的怎样的影响。首先,我澄清了炎症和体温的关系。已知热休克蛋白(HSP)对侵袭具有细胞保护作用。制作大鼠内毒素休克模型,观察诱导热休克后的保护作用。结果表明,添加热应激(42℃15min)诱导热休克,可明显抑制炎症反应,提高成活率。今后我将进一步推进体温及其与粘蛋白表达关系的研究。
英文摘要
Inflammation lets mucin in the respiratory duct increase,but does not understand whether expression of mucin comes under what kind of influence by abnormal body temperature. First of all, I clarified relations of inflammation and body temperature. It is known that we have cytoprotective protection effect for aggression in heat shock protein (HSP). I made a rat endotoxin shock model and examined protection effect when I induced HSP. As s result, it was recognized that HSP was induced by adding heat stress (42℃15minutes), and inhibited inflammation significantly, and improved the survival rate. I will push forward study about body temperature and relations with expression of mucin more in future.
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DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [長谷川輝, 岩坂日出男, 萩原聡, 野口隆之, 長谷川輝, 長谷川輝]
通讯作者: 長谷川輝
DOI: 10.1016/j.jss.2009.10.015
发表时间: 2011-07-01
期刊: JOURNAL OF SURGICAL RESEARCH
影响因子: 2.2
作者: [Hasegawa, Akira, Iwasaka, Hideo, Noguchi, Takayuki]
通讯作者: Noguchi, Takayuki
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