New drug delivery into inner ear ; possibility of the treatment withnano technology

考察了纳米颗粒的药物递送至内耳的潜力。Qdot 655分别与辣根过氧化物酶（HRP）、半乳糖凝集素-1（Galectin-1）、L-谷氨酰胺酸（L-GlutaminAcid）和表皮生长因子（EGF）等多肽偶联。将Qdot注入豚鼠耳蜗中阶后，将Qdot与Galectin 1和EGF一起导入Corti器和Reissner膜。纳米粒子有望用于治疗内耳疾病。

Nano particle was examined for the potential of drug delivery to inner ear. Qdot 655 was conjugated respectively with several peptides which are horseradish peroxidase(HRP), Galectin-1, L-Glutamin Acid and epidermal growth factor(EGF). When Qdot was injected into scala media of the cochlea in guinea pig, Qdots with Galectin 1 and EGF were introduced into organ of Corti and Reissner's membrane. Nano particle is expected as treatment for inner ear disease.