Fluorous Chemistry: New tagging agents and heterocyclic-based fluorous surfactants

氟化学正在成为传统平行和组合有机合成领域的一个强有力的辅助手段，它的引入彻底改变了分离技术。本计画将探讨两种新的氟标记策略，以扩大可用于合成的试剂范围。努力将针对手性助剂和氟催化剂配体。此外，一类新的氟表面活性剂将被调查，其表面特性（包括其自组装能力）和其在两个特定的应用程序，选择性膜结合蛋白质提取（相关的蛋白质组学）和眼科（生物材料）的效用。

Fluorous chemistry is emerging as a powerful adjunct to areas of conventional parallel and combinatorial organic syntheses, and its introduction has revolutionised separation technologies. In this project two new fluorous tagging strategies will be investigated in an effort to broaden the scope of reagents that can used in synthesis. Efforts will be directed to chiral auxiliaries and to fluorous catalyst ligands. In addition, a novel class of fluorous surfactant will be investigated, for its surface properties (including its ability to self assemble) and for its utility in two specific applications, selective membrane-bound protein extraction (relevant to proteomics) and ophthalmics (biomaterials).